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Minerals such as calcium and magnesium are most effective when reacting with stomach acid on an empty stomach. While taking them on an empty stomach is recommended, it is advisable to take them after a meal if you have gastrointestinal issues. Mineral supplements containing calcium, magnesium, iron, zinc, and selenium can inhibit absorption due to mutual competition. When consuming high doses of a single ingredient, it is best to take them with a time interval between doses.